Therapeutic drug monitoring status of four common antibiotics: vancomycin, meropenem, linezolid and teicoplanin.

This study focuses on therapeutic drug monitoring status of four common antibiotics: vancomycin, meropenem, linezolid and teicoplanin.. The research employs high-performance liquid chromatography (HPLC) techniques to address analytical challenges in the clinical field. Accurate therapeutic drug monitoring (TDM) of vancomycin, meropenem, linezolid and teicoplanin are conducive to developing optimal therapeutic regimes for patients. However, the measurement status of those drugs in different laboratories has not been reported. In this study, four samples including two frozen plasma samples and two lyophilized plasma samples were...

This study focuses on therapeutic drug monitoring status of four common antibiotics: vancomycin, meropenem, linezolid and teicoplanin.. The research employs high-performance liquid chromatography (HPLC) techniques to address analytical challenges in the clinical field. Accurate therapeutic drug monitoring (TDM) of vancomycin, meropenem, linezolid and teicoplanin are conducive to developing optimal therapeutic regimes for patients. However, the measurement status of those drugs in different laboratories has not been reported. In this study, four samples including two frozen plasma samples and two lyophilized plasma samples were... Research Background and Significance Therapeutic drug monitoring (TDM) is a critical clinical practice aimed at optimizing antibiotic dosing to maximize efficacy while minimizing toxicity. Among antibiotics, vancomycin, meropenem, linezolid, and teicoplanin are frequently used to treat severe infections, often in critically ill patients. However, due to their narrow therapeutic windows and variable pharmacokinetics, precise monitoring of their plasma concentrations is essential. Despite the clinical importance, standardized, validated methods for simultaneous or individual quantification of these antibiotics remain limited, and inter-laboratory variability in measurement techniques can hinder consistent patient care. This study addresses this gap by applying high-performance liquid chromatography (HPLC) methodologies to evaluate the therapeutic drug monitoring status of these four antibiotics, thereby supporting optimal dosing regimens and improving clinical outcomes. Experimental Design and Methodology The authors implemented a robust HPLC analytical method tailored for clinical plasma samples to quantify vancomycin, meropenem, linezolid, and