Therapeutic Drug Monitoring in Arterial Hypertension.

This study focuses on therapeutic drug monitoring in arterial hypertension.. The research employs high-performance liquid chromatography (HPLC) techniques to address analytical challenges in the clinical field. (1) Background: This study was planned to assess the concentration of antihypertensive drugs (AHD) in the blood serum in patients with controlled and uncontrolled arterial hypertension (AH). (2) Methods: We assessed 46 patients with AH. Based on the results of 24 h blood pressure monitoring (ABPM), the patients were randomized... Research Background and Significance Arterial hypertension (AH) remains a prevalent cardiovascular disorder with significant morbidity and mortality worldwide. Achieving optimal therapeutic control in patients is often complicated by interindividual variability in drug pharmacokinetics and adherence issues. Therapeutic drug monitoring (TDM) of antihypertensive drugs (AHD) in serum offers a valuable approach to individualize treatment, ensure compliance, and optimize efficacy. The study by Seleznev et al. (2023) addresses the critical need for sensitive, reliable, and validated analytical methods to quantify AHD concentrations in clinical settings. By leveraging high-performance liquid chromatography (HPLC), the authors aim to overcome analytical challenges such as matrix complexity, low analyte concentrations, and the need for rapid and reproducible assays. This work is significant as it provides a methodological foundation for personalized medicine approaches in hypertension management, aligning with current trends toward precision therapeutics. Experimental Design and Methodology The study enrolled 46 patients diagnosed with arterial hypertension, categorized into controlled and uncontrolled groups based on 24-hour ambulatory blood pre