Therapeutic drug monitoring in anti-tuberculosis treatment: a systematic review.

This study focuses on therapeutic drug monitoring in anti-tuberculosis treatment: a systematic review.. The research employs high-performance liquid chromatography (HPLC) techniques to address analytical challenges in the clinical field. The treatment of tuberculosis (TB) depends on anti-TB drugs to eradicate the infection and prevent its transmission. Variability in drug metabolism, interactions, and adherence can affect treatment efficacy. Therapeutic drug monitoring (TDM) is essential for optimizing treatment by adjusting dosages. This systematic review aimed to assess the effectiveness of TDM... Research Background and Significance Tuberculosis (TB) remains a significant global health challenge, with millions affected annually. Effective anti-tuberculosis treatment relies heavily on the administration of multiple drugs over prolonged periods. However, variability in patient response caused by factors such as drug metabolism differences, drug-drug interactions, and adherence inconsistencies can compromise therapeutic outcomes. Therapeutic drug monitoring (TDM) emerges as a critical tool in this context, enabling clinicians to tailor dosing regimens based on measured drug concentrations in biological fluids. The systematic review by Metarfi et al. underscores the importance of precise, reliable analytical methods—specifically high-performance liquid chromatography (HPLC)—to facilitate accurate TDM in clinical settings. By focusing on validated chromatographic methodologies, the study highlights how HPLC can overcome analytical challenges inherent to anti-TB drug quantification, ultimately supporting improved patient management and treatment efficacy. Experimental Design and Methodology The systematic review synthesized data from multiple studies employing HPLC techniq