Simultaneous Determination and Exposure Assessment of Antioxidants in Food-Contact Plastic Materials by HPLC-MS/MS.

This study focuses on simultaneous determination and exposure assessment of antioxidants in food-contact plastic materials by hplc-ms/ms.. The research employs high-performance liquid chromatography (HPLC) techniques to address analytical challenges in the food safety field. Antioxidants are widely used to prevent oxidative degradation of food-contact plastics materials. However, when plastic products come into contact with food, antioxidants may contaminate food. Herein, twenty-three kinds of possible antioxidants were monitored in 257 products of seven polymers. The migration of antioxidants into the food simulants at different temperatures... Research Background and Significance The integrity and safety of food-contact materials are paramount concerns in the food industry, as contaminants migrating from packaging can directly affect human health. Antioxidants are commonly incorporated into food-contact plastics to prevent oxidative degradation, thereby extending product shelf life and maintaining material performance. However, these additives have the potential to migrate into foodstuffs during storage, which poses a risk of consumer exposure to chemical substances. Monitoring and quantifying antioxidants in food-contact plastics is therefore essential for regulatory compliance and risk assessment. The study by Liu et al. (2023) addresses this critical issue by developing a robust HPLC-MS/MS method for the simultaneous determination of 23 antioxidants across multiple polymer types, advancing analytical capabilities in food safety evaluation. Experimental Design and Methodology The research employed a comprehensive approach combining high-performance liquid chromatography with tandem mass spectrometry (HPLC-MS/MS) to achieve sensitive, selective, and simultaneous quan