Recent developments in electromigration techniques related to pharmaceutical and biomedical analysis - A review.

This study focuses on recent developments in electromigration techniques related to pharmaceutical and biomedical analysis - a review.. The research employs high-performance liquid chromatography (HPLC) techniques to address analytical challenges in the pharmaceutical field. The analysis of pharmaceutical compounds is an important research topic as the use of different drugs affects people's daily life for the treatment of diseases. In addition to the widespread use of the internet, counterfeit drugs have appeared in the market. The development of modern analytical techniques, reliable, precise, sensitive,... Research Background and Significance The pharmaceutical industry continuously demands robust, sensitive, and reliable analytical techniques to ensure drug quality, safety, and efficacy. Electromigration techniques, including capillary electrophoresis and related modalities, have gained prominence due to their high separation efficiency and minimal sample requirements. However, high-performance liquid chromatography (HPLC) remains a cornerstone in pharmaceutical analysis due to its versatility and established regulatory acceptance. The reviewed article provides a comprehensive overview of recent advancements in electromigration techniques with a specific focus on their integration or complementary use with HPLC methodologies. This review underscores the critical need for analytical methods capable of addressing challenges such as counterfeit drug detection, complex biological matrices, and trace-level quantification of pharmaceutical compounds. By highlighting the role of modern HPLC techniques, the study emphasizes improvements in precision, sensitivity, and method validation—key factors ensuring reliable pharmaceutical analysis in both research and quality control