Quantitative-HPLC-DAD polyphenols analysis, anxiolytic and cognition enhancing potentials of Sorbaria tomentosa Lindl. Rehder.

This study focuses on quantitative-hplc-dad polyphenols analysis, anxiolytic and cognition enhancing potentials of sorbaria tomentosa lindl. rehder.. The research employs high-performance liquid chromatography (HPLC) techniques to address analytical challenges in the pharmaceutical field. Medicinal plants of the family Rosaceae have a long history of traditional uses in the management of neurological disorders. Sorbaria tomentosa Lindl. Rehder is composed of antioxidant and neuroprotective polyphenolics.... Research Background and Significance Polyphenols are bioactive compounds widely recognized for their antioxidant and neuroprotective properties, making them critical targets in pharmaceutical and nutraceutical research. Sorbaria tomentosa Lindl. Rehder, a species belonging to the Rosaceae family, has been traditionally used in ethnomedicine for managing neurological disorders, particularly those related to anxiety and cognitive impairment. Despite its traditional relevance, comprehensive quantitative analysis of its polyphenolic content to correlate with pharmacological effects had been limited prior to this study. The application of High-Performance Liquid Chromatography coupled with Diode Array Detection (HPLC-DAD) provides a robust and precise analytical approach to quantify these bioactive constituents. This study by Mahnashi et al. (2023) fills a critical gap by developing and validating an HPLC-DAD method tailored for the analysis of polyphenols in Sorbaria tomentosa extracts, while simultaneously exploring its anxiolytic and cognition enhancing potentials. The research underscores the relevance of advanced chromatographic techniques in bridging phytochemical profiling with pharmacological efficacy, thereby supporting the advancement of plant-based drug discove