Migration of bisphenol A from commercially available pacifiers: HPLC-FLD analysis and exposure assessment in infants and toddlers.

This study focuses on migration of bisphenol a from commercially available pacifiers: hplc-fld analysis and exposure assessment in infants and toddlers.. The research employs high-performance liquid chromatography (HPLC) techniques to address analytical challenges in the environmental field. Bisphenol A (BPA) is an endocrine-disrupting compound widely used in plastics and resins and associated with metabolic, reproductive, and neurodevelopmental disorders. Infants and toddlers are particularly vulnerable because detoxification capacity is immature and exposure occurs during sensitive developmental stages. While BPA is banned in infant feeding bottles within the European... Research Background and Significance Bisphenol A (BPA) is a well-known endocrine-disrupting chemical extensively used in the manufacture of polycarbonate plastics and epoxy resins. Due to its widespread use in consumer products, including infant feeding bottles, pacifiers, and other plastic items, BPA exposure has become a significant public health concern. Particularly vulnerable to BPA exposure are infants and toddlers, whose developing metabolic and detoxification systems are immature, increasing their susceptibility to adverse effects. BPA has been linked to metabolic, reproductive, and neurodevelopmental disorders, highlighting the need for sensitive and reliable analytical methods to quantify BPA migration from consumer products. Regulatory agencies in Europe and worldwide have banned BPA use in infant feeding bottles; however, its presence in other infant-related products such as pacifiers remains a concern. This study addresses the analytical challenges associated with detecting BPA migration from commercially available pacifiers into simulant solutions, employing high-performance liquid chrom