HPLC-DAD Analysis and Versatile Bioactivities of Turkish Sunflower Honeys Using Chemometric Approaches.

This study focuses on hplc-dad analysis and versatile bioactivities of turkish sunflower honeys using chemometric approaches.. The research employs high-performance liquid chromatography (HPLC) techniques to address analytical challenges in the food safety field. Sunflower honey (SH) is bright yellow, fragrant, pollen-flavoured, slightly herbaceous and has a unique taste. The present research aims to examine the enzyme inhibitory, antioxidant, anti-inflammatory, antimicrobial and anti-quorum sensing activities and phenolic compositions of 30 sunflower honeys (SHs) produced from several regions of Turkey with chemometric study. SAH from... Research Background and Significance Honey is a complex natural product with diverse bioactive compounds, making it a valuable subject for food safety and quality research. Turkish sunflower honey (SH), known for its bright yellow color, fragrant aroma, and unique pollen-flavored, slightly herbaceous taste, presents a rich matrix for analytical characterization. The phenolic profile of honey is directly linked to its antioxidant, antimicrobial, and other health-related bioactivities. High-performance liquid chromatography (HPLC) coupled with diode array detection (DAD) is a powerful tool to accurately identify and quantify phenolic compounds in complex matrices such as honey. This study leverages chemometric approaches alongside HPLC-DAD analysis to not only profile the phenolic compounds in sunflower honeys from various Turkish regions but also to evaluate their enzyme inhibitory, antioxidant, anti-inflammatory, antimicrobial, and anti-quorum sensing activities. This comprehensive approach addresses both the chemical composition and functional bioactivities, providing critical insights into food safety and potential therapeutic applic