Eco-friendly chitosan microspheres as a novel one-step sorbent for the rapid purification and determination of pesticides and veterinary drug multi-residues in aquatic products with HPLC-MS/MS.

This study focuses on eco-friendly chitosan microspheres as a novel one-step sorbent for the rapid purification and determination of pesticides and veterinary drug multi-residues in aquatic products with hplc-ms/ms.. The research employs high-performance liquid chromatography (HPLC) techniques to address analytical challenges in the food safety field. A modified QuEChERS method was developed to determine multi-class pesticide and veterinary residues in aquatic products. Chitosan microspheres were conveniently synthesized and utilized as the cleanup adsorbent in the QuEChERS procedure, showcasing rapid filtration one-step pretreatment ability for the determination of drug multi-residues in aquatic products. Compared to conventional synthetic... Research Background and Significance The presence of pesticide and veterinary drug residues in aquatic products poses significant risks to food safety and public health. Regulatory agencies worldwide enforce strict maximum residue limits (MRLs) to ensure consumer protection, necessitating robust, sensitive, and rapid analytical methods for multi-residue detection. Traditional sample preparation techniques often involve time-consuming, multi-step procedures that can generate chemical waste and incur high operational costs. This study by Zhou et al. introduces eco-friendly chitosan microspheres as a novel sorbent material integrated into a modified QuEChERS (Quick, Easy, Cheap, Effective, Rugged, and Safe) approach to streamline the purification process. Chitosan, a natural polysaccharide derived from chitin, is biodegradable, non-toxic, and offers excellent adsorption properties due to its high surface area and functional groups. By leveraging these microspheres, the research aims to develop a one-step, rapid pretreatment method th