Chemometric-Based AQbD and Green Chemistry Approaches to Chromatographic Analysis of Remogliflozin Etabonate and Vildagliptin.

This study focuses on chemometric-based aqbd and green chemistry approaches to chromatographic analysis of remogliflozin etabonate and vildagliptin.. The research employs high-performance liquid chromatography (HPLC) techniques to address analytical challenges in the environmental field. According to the green chemistry approach, during method development, the usage of toxic and carcinogenic organic solvents should be avoided or minimized for the safety of the environment and analysts. The chromatographic methods such as reverse-phase high-pressure liquid chromatography (RP-HPLC) and high-performance thin-layer chromatography (HPTLC) include the usage of class...

This study focuses on chemometric-based aqbd and green chemistry approaches to chromatographic analysis of remogliflozin etabonate and vildagliptin.. The research employs high-performance liquid chromatography (HPLC) techniques to address analytical challenges in the environmental field. According to the green chemistry approach, during method development, the usage of toxic and carcinogenic organic solvents should be avoided or minimized for the safety of the environment and analysts. The chromatographic methods such as reverse-phase high-pressure liquid chromatography (RP-HPLC) and high-performance thin-layer chromatography (HPTLC) include the usage of class... Research Background and Significance The study titled "Chemometric-Based AQbD and Green Chemistry Approaches to Chromatographic Analysis of Remogliflozin Etabonate and Vildagliptin" addresses the growing demand for environmentally conscious and robust analytical methods in pharmaceutical and environmental analysis. Remogliflozin etabonate and vildagliptin are antidiabetic agents whose environmental trace detection is increasingly important due to their widespread use and potential ecological impact. Traditionally, chromatographic methods often employ toxic organic solvents, posing health risks and environmental hazards. This research integrates chemometric tools within an Analytical Quality by Design (AQbD) framework to optimize chromatographic conditions while adhering to green chemistry principles. The significance lies in establishing a validated high-performance liquid chromatography (HPLC) method that not only ensures analytical accuracy and precision but also minimizes environmental footprint, aligning with regulatory and sustainability goals in analytical sciences. Experimental Design and Methodology The