A green approach for metoclopramide quantification in pharmaceutical products: new HPLC and spectrophotometric methods.

This study focuses on a green approach for metoclopramide quantification in pharmaceutical products: new hplc and spectrophotometric methods.. The research employs high-performance liquid chromatography (HPLC) techniques to address analytical challenges in the pharmaceutical field. Green spectrophotometric and HPLC methods have been developed for the quantification of metoclopramide. In the spectrophotometric method, it was determined by direct absorbance measurement at 273 nm wavelength using ultrapure water as solvent. The Extend C18 column was used for the HPLC method. The mobile phase system consisted of a...

This study focuses on a green approach for metoclopramide quantification in pharmaceutical products: new hplc and spectrophotometric methods.. The research employs high-performance liquid chromatography (HPLC) techniques to address analytical challenges in the pharmaceutical field. Green spectrophotometric and HPLC methods have been developed for the quantification of metoclopramide. In the spectrophotometric method, it was determined by direct absorbance measurement at 273 nm wavelength using ultrapure water as solvent. The Extend C18 column was used for the HPLC method. The mobile phase system consisted of a... Research Background and Significance Metoclopramide is a widely used pharmaceutical agent primarily employed as an antiemetic and gastroprokinetic drug. Accurate quantification of metoclopramide in pharmaceutical formulations is essential to ensure dosage accuracy, efficacy, and patient safety. Traditional analytical methods often rely on organic solvents and involve complex sample preparation steps, which can have environmental and economic drawbacks. The study by Demir et al. (2024) addresses these concerns by developing a green analytical approach that integrates both high-performance liquid chromatography (HPLC) and spectrophotometric techniques. This research is significant as it aligns with the increasing demand for sustainable and environmentally friendly analytical protocols in pharmaceutical quality control. By minimizing the use of hazardous solvents and simplifying the methodology, the study contributes to greener pharmaceutical analytics without compromising sensitivity and reliability. Experimental Design and Methodology The study utilized a reversed-phase HPLC method coupled with a spectrophotometric approach to quantify metoclopramide in pharmace